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KMID : 0895420070170030181
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Journal of Korean Society of Occupational and Enviromental Hygiene
2007 Volume.17 No. 3 p.181 ~ p.191
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A Study on the Subchronic Inhalation Toxicity of 2 Butanethiol Using SD Rats
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Kim Hyeon-Yeong
Lee Sung-Bae
Lim Cheol-Hong
Cho Hae-Won
Kang Min-Gu
Lee Jun-Yeon
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Abstract
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With the 2-Butanethiol, which is an unidentified inhalation toxic material, acute inhalation toxicity was tested with SD rats. The LC50 was evaluated to be 2,500 ppm (9.22 mg/L) or higher which falls under the criteria of acute toxicity Category 3 (500400 ppm, 6 hours a day, 5 days a week, for 13 weeks repeated exposure, though no death or particular clinical resentation was observed, in the female 25 and 400 ppm group, including weight change, and in each concentration group including 400 ppm, change of feed rate, eye stimulation, motility change in male group, and lesions in blood and blood biochemical were observed. In the internal organs weight, 25, 100, and 400 ppm groups in male and 400 ppm group in female showed significant (p<0.05) changes in kidney, liver, thymus, and lung. In the pathological tissue test, severe cortical tubular hyaline droplets were observed in the male 400 ppm group, and all male rats of 400 ppm group and 2 female individuals showed tubular degeneration/regeneration accompanied with pigmentation, showing that the target organs of inhalation exposure of 2- Butanethiol are spleen, kidney, nasal cavity, and adrenal. Through the tests, the NOEL of 2-Butanethiol was evaluated to be 25 ppm (0.092 mg/L) or less for both male and female.
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KEYWORD
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2-Butanethiol, Inhalation Toxicity, LC50, GHS, NOEL
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